Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles

Seong Gi Kim, Noam Harel, Tao Jin, Tae Kim, Phil Lee, Fuqiang Zhao

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-half-life, intravascular susceptibility agents of CBV MRI measurements. Moreover, CBV-weighted functional MRI (fMRI) with USPIO nanoparticles provides enhanced sensitivity, reduced large vessel contribution and improved spatial specificity relative to conventional blood oxygenation level-dependent fMRI, and measures a single physiological parameter that is easily interpretable. We review the physiochemical and magnetic properties, and pharmacokinetics, of USPIO nanoparticles in brief. We then extensively discuss quantifications of baseline CBV, vessel size index and functional CBV change. We also provide reviews of dose-dependent sensitivity, vascular filter function, specificity, characteristics and impulse response function of CBV fMRI. Examples of CBV fMRI specificity at the laminar and columnar resolution are provided. Finally, we briefly review the application of CBV measurements to functional and pharmacological studies in animals. Overall, the use of USPIO nanoparticles can determine baseline CBV and its changes induced by functional activity and pharmacological interventions.

Original languageEnglish (US)
Pages (from-to)949-962
Number of pages14
JournalNMR in biomedicine
Issue number8
StatePublished - Aug 2013


  • Cerebral blood volume
  • Contrast agent
  • Cortical columns
  • FMRI
  • Iron oxide
  • Monocrystalline iron oxide nanoparticle (MION)
  • Pharmacological MRI
  • Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles


Dive into the research topics of 'Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles'. Together they form a unique fingerprint.

Cite this