Cervical cancers manifest a high rate of infection by a high-risk human papilloma virus subtype but a very low rate of infection by a low-risk subtype in the Guiyang District of China

Juan Peng, Yan Yuan, Feng Shen, Yan Wang, Lichan Chen, D. Liao

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36.98%. Most (72.08%) infectors were positive for only one HPV subtype, with the remaining being cases infected by two or more subtypes. Infections by the HPV subtypes 16, 52 and 58 were the most prevalent, having rates of 34.66%, 16.03%%and 15.53%, respectively. The most common cervical lesions in HPV infections were genital warts, cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). Age and age at first sexual activity were independent risk factors for HPV infections that in turn cause certain cervical lesions. Intriguingly, while 94.90%of the CC patients were infected by oncogenically high-risk (HR) HPV subtypes, only 2.75%and 2.29%of these patients were infected by oncogenically low-risk (LR) subtypes or other-subtypes with their oncogenicity unclear. The rates of infection by LR-HPVs and other-HPVs were also low, being 4.63%and 6.76%, respectively, in the patients with CIN that is a precursor lesion of CC, lower than the 8.54%and 18.20%, respectively, in the women without a cervical lesion. Our data provides an important foundation for prevention, diagnosis and treatment of HPV infection in Guiyang district and suggests that development of vaccines for prevention and treatment of CC in this area should first target the HPV subtypes 16, 52 and 58, but not subtype 18 as for many other places. It deserves study whether infections by certain LR-HPVs and other-HPVs may serve as attenuated live vaccines for prevention of CC.

Original languageEnglish (US)
Pages (from-to)1263-1270
Number of pages8
JournalJournal of Cancer
Volume8
Issue number7
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
We thank Wei Wang for specimen collection and YingJie Yang for the excellent technical assistance. We would also like to thank Dr. Fred Bogott at the Austin Medical Center, Austin of Minnesota, USA, for his excellent English editing of the manuscript. This work was supported by the Science and Technology Bureau of Guiyang City (Grant No. 31360544 to YJ Tan) and by the Department of Science and Technology of Guizhou Province (No.2011037 to YJ Tan).

Keywords

  • Epidemiology investigation
  • Genotypes
  • Human papillomavirus
  • Infection

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