TY - JOUR
T1 - Chagas disease
T2 - Still many unsolved issues
AU - Álvarez, José M.
AU - Fonseca, Raissa
AU - Borges Da Silva, Henrique
AU - Marinho, Cláudio R.F.
AU - Bortoluci, Karina R.
AU - Sardinha, Luiz R.
AU - Epiphanio, Sabrina
AU - D'Império Lima, Maria Regina
PY - 2014
Y1 - 2014
N2 - Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: "Why does the host immune system fail to provide sterile immunity?" and "Why do only a proportion of infected individuals develop chronic pathology?" In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology.
AB - Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: "Why does the host immune system fail to provide sterile immunity?" and "Why do only a proportion of infected individuals develop chronic pathology?" In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology.
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U2 - 10.1155/2014/912965
DO - 10.1155/2014/912965
M3 - Review article
C2 - 25104883
AN - SCOPUS:84904650071
SN - 0962-9351
VL - 2014
JO - Mediators of inflammation
JF - Mediators of inflammation
M1 - 912965
ER -