Changes in circulating leptin levels during the initial stage of cessation are associated with smoking relapse

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Rationale: Leptin has been linked to tobacco craving and withdrawal-related symptoms. Very few studies have examined leptin prospectively in both male and female nonsmokers and smokers. Objectives: We examine leptin concentrations prospectively in both male and female nonsmokers and smokers to assess the associations of leptin with psychological symptoms and smoking relapse during ad libitum smoking, the first 48 h post quit, and 4 weeks post-cessation. Methods: Self-report psychological, anthropomorphic, and biological measures (cotinine, carbon monoxide, and plasma leptin) were collected before and after 48 h of smoking abstinence. Smokers were stratified at 28 days post quit as abstinent or relapsed if they had smoked daily for seven consecutive days at any point in the 28 days. Results: Leptin concentration (square root transformed ng/ml) increased over the 48-h abstinence, but only in female abstainers. In contrast, leptin was very stable across time for nonsmokers, relapsers, and males. Cox regression supported that increased leptin was associated with decreased risk of relapse. Leptin was correlated negatively with withdrawal symptoms for abstainers only. Females produce more leptin than males and this level increases from ad libitum smoking to 48-h post quit. Conclusions: The current analysis indicates that a leptin increase early in cessation predicts abstinence. The increase in women, but not men, in response to abstinence provides further evidence of important gender differences. The negative correlation between leptin and withdrawal symptoms indicates a possible protective effect of leptin. Further research is ongoing to elucidate the psychological and biological determinants of this effect.

Original languageEnglish (US)
Pages (from-to)3355-3361
Number of pages7
JournalPsychopharmacology
Volume232
Issue number18
DOIs
StatePublished - Sep 17 2015

Keywords

  • Gender
  • Leptin
  • Nicotine
  • Prospective
  • Relapse
  • Smoking
  • Tobacco
  • Withdrawal

Fingerprint Dive into the research topics of 'Changes in circulating leptin levels during the initial stage of cessation are associated with smoking relapse'. Together they form a unique fingerprint.

Cite this