Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.
Bibliographical noteFunding Information:
The research was supported by the Medical Research Service of the Veterans Administration and the Geriatric Research, Education, and Clinical Center of the Veterans Administration Medical Center, St. Louis~ MO. The authors gratefully acknowledge the excellent secretarial assistance of Mrs. Sandy Melliere and Mrs. Cheryl Duff.