TY - JOUR
T1 - Changes over 14 years in androgenicity and body mass index in a biracial cohort of reproductive-age women
AU - Sternfeld, Barbara
AU - Liu, Kiang
AU - Quesenberry, Charles P.
AU - Wang, Hua
AU - Jiang, Sheng Fang
AU - Daviglus, Martha
AU - Fornage, Myriam
AU - Lewis, Cora E.
AU - Mahan, John
AU - Schreiner, Pamela J.
AU - Schwartz, Stephen M.
AU - Sidney, Stephen
AU - Williams, O. Dale
AU - Siscovick, David S.
N1 - Funding Information:
This research was supported by a grant from the National Heart, Lung, and Blood Institute (R01-HL065611) and contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, and N01-HC-48050.
PY - 2008/6
Y1 - 2008/6
N2 - Background: Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time. Methods: Participants included 969 White and Black women from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, who were ages 18-30 at entry into the study and were pre- or perimenopausal 16 yr later at the time of the CARDIA Women's Study (CWS). Total T and SHBG were assayed from specimens drawn at the CWS examination and stored serum from the yr 2 and 10 CARDIA exams. Free T was calculated based on total T and SHBG. BMI and waist circumference were measured at yr 2, 10, and 16. Results: Despite clinically significant increases in BMI and waist circumference, total T and free T tended to decline, whereas SHBG remained relatively constant. BMI and waist circumference were directly correlated with free T and inversely correlated with SHBG in cross-sectional analyses. In longitudinal, multivariable analyses, an annualized increase in BMI was inversely related to a concurrent annualized decrease in SHBG (β = -0.79 ng/dl, and SE = 0.22 in Blacks; β = -1.07 ng/dl; and SE = 0.31 in Whites). However, early increases in BMI were not related to later decreases in SHBG. Conclusion: Increases in adiposity are closely tied to decreases in SHBG, but changes in BMI and SHBG may occur concurrently rather than sequentially.
AB - Background: Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time. Methods: Participants included 969 White and Black women from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, who were ages 18-30 at entry into the study and were pre- or perimenopausal 16 yr later at the time of the CARDIA Women's Study (CWS). Total T and SHBG were assayed from specimens drawn at the CWS examination and stored serum from the yr 2 and 10 CARDIA exams. Free T was calculated based on total T and SHBG. BMI and waist circumference were measured at yr 2, 10, and 16. Results: Despite clinically significant increases in BMI and waist circumference, total T and free T tended to decline, whereas SHBG remained relatively constant. BMI and waist circumference were directly correlated with free T and inversely correlated with SHBG in cross-sectional analyses. In longitudinal, multivariable analyses, an annualized increase in BMI was inversely related to a concurrent annualized decrease in SHBG (β = -0.79 ng/dl, and SE = 0.22 in Blacks; β = -1.07 ng/dl; and SE = 0.31 in Whites). However, early increases in BMI were not related to later decreases in SHBG. Conclusion: Increases in adiposity are closely tied to decreases in SHBG, but changes in BMI and SHBG may occur concurrently rather than sequentially.
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U2 - 10.1210/jc.2007-2203
DO - 10.1210/jc.2007-2203
M3 - Article
C2 - 18334590
AN - SCOPUS:45149095441
SN - 0021-972X
VL - 93
SP - 2158
EP - 2165
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 6
ER -