TY - JOUR
T1 - Chaperone-mediated cross-priming
T2 - a hitchhiker's guide to vesicle transport (review).
AU - Reed, Robyn C
AU - Nicchitta, C. V.
PY - 2000/9
Y1 - 2000/9
N2 - The resident endoplasmic reticulum (ER) chaperone proteins GRP94 (gp96) and calreticulin can activate the immune system to slow or stop the progression of tumors by escorting tumor-derived peptides into the endogenous antigen presentation pathway of antigen presenting cells (APC). Although the phenomenology of cross-priming is well worked out, the mechanism(s) remains unclear. Continuing insights into cellular protein trafficking pathways suggest several means by which chaperones could travel from the extracellular space into the endosome, lysosome or ER of APC. In particular, proteins that cycle between two or more compartments and those that undergo and mediate retrograde flow offer models of how exogenous chaperones might travel in the APC. New insights into how non-chaperone proteins access the APC antigen presentation pathway also suggest several ways this process could occur.
AB - The resident endoplasmic reticulum (ER) chaperone proteins GRP94 (gp96) and calreticulin can activate the immune system to slow or stop the progression of tumors by escorting tumor-derived peptides into the endogenous antigen presentation pathway of antigen presenting cells (APC). Although the phenomenology of cross-priming is well worked out, the mechanism(s) remains unclear. Continuing insights into cellular protein trafficking pathways suggest several means by which chaperones could travel from the extracellular space into the endosome, lysosome or ER of APC. In particular, proteins that cycle between two or more compartments and those that undergo and mediate retrograde flow offer models of how exogenous chaperones might travel in the APC. New insights into how non-chaperone proteins access the APC antigen presentation pathway also suggest several ways this process could occur.
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U2 - 10.3892/ijmm.6.3.259
DO - 10.3892/ijmm.6.3.259
M3 - Review article
C2 - 10934286
AN - SCOPUS:0034265858
SN - 1107-3756
VL - 6
SP - 259
EP - 264
JO - International journal of molecular medicine
JF - International journal of molecular medicine
IS - 3
ER -