CHAPTER 9: Big Data Integration and Inference

Karen H. Watanabe-Sailor, Hristo Aladjov, Shannon M. Bell, Lyle Burgoon, Wan Yun Cheng, Rory Conolly, Stephen W. Edwards, Nàtalia Garcia-Reyero, Michael L. Mayo, Anthony Schroeder, Clemens Wittwehr, Edward J. Perkins

    Research output: Chapter in Book/Report/Conference proceedingChapter


    Toxicology data are generated on large scales by toxicogenomic studies and high-throughput screening (HTS) programmes, and on smaller scales by traditional methods. Both big and small data have value for elucidating toxicological mechanisms and pathways that are perturbed by chemical stressors. In addition, years of investigations comprise a wealth of knowledge as reported in the literature that is also used to interpret new data, though knowledge is not often captured in traditional databases. With the big data era, computer automation to analyse and interpret datasets is needed, which requires aggregation of data and knowledge from all available sources. This chapter reviews ongoing efforts to aggregate toxicological knowledge in a knowledge base, based on the Adverse Outcome Pathways framework, and provides examples of data integration and inferential analysis for use in (predictive) toxicology.

    Original languageEnglish (US)
    Title of host publicationBig Data in Predictive Toxicology
    EditorsDaniel Neagu, Andrea-Nicole Richarz
    PublisherRoyal Society of Chemistry
    Number of pages43
    StatePublished - Jan 1 2020

    Publication series

    NameIssues in Toxicology
    ISSN (Print)1757-7179
    ISSN (Electronic)1757-7187


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