Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

Marc G. Ghany; Robert Perrillo; Ruosha Li; Steven H. Belle; Harry L A Janssen; Norah A. Terrault; Margaret C. Shuhart; Daryl T Y Lau; W. Ray Kim; Michael W. Fried; Richard K. Sterling; Adrian M. Di Bisceglie; Steven Huy B Han; Lilia Milkova Ganova-Raeva; Kyong Mi Chang; Anna Suk Fong Lok; Raymond T. Chung; Lewis R. Roberts; Coleman I. Smith; Mauricio Lisker-Melman; David K. Wong; Joshua Juan; Jordan Feld; Colina Yim; Jenny Heathcoate; William M. Lee; Son Do; Tram T. Tran; Mandana Khalili; Stewart L. Cooper; Robert J. Fontana; Naoky Tsai; Keyur Patel; Donna Evon; Robert C. Carithers; Kris V. Kowdley; Chia C. Wang; T. Jake Liang; Jang June Park; Abdus Wahed; David Kleiner; Nezam Afdhal; Asad Javaid; Jianghe Niu; Johanna Han; Imad Nasser; Alisha C. Stahler; Linda Stadheim; Mohamed Hassan; Debra L. King; Rosemary A. Nagy; Danie La; Lucie Liu; Stacey Minshall; Sheila Bass; Samuel French; Velma Peacock; Ashley Ungermann; Claudia Ayala; Emma Olson; Ivy Lau; Veronika Podolskaya; Nata DeVole; Barbara McKenna; Kelly Oberhelman; Sravanthi Kaza; Cassandra Rodd; Leslie Huddleston; Peter Poerzgen; Jama M. Darling; A. Sidney Barritt; Tiffany Marsh; Vikki Metheny; Danielle Cardona; Velimir A. Luketic; Paula G. Smith; Charlotte Hofmann; Terri Mathisen; Susan Strom; Jody Mooney; Lupita Cardona-Gonzalez; Nancy Fryzek; Elenita Rivera; Nevitt Morris; Vanessa Haynes-Williams; Mary E. Valiga; Keith Torrey; Danielle Levine; James Keith; Michael Betts; Luis J. Montaner; Chong Gee Teo; Yury Khudyakov; Lili T. Punkova; Yona Cloonan; Michelle Danielson; Tamara Haller; Geoffrey Johnson; Stephanie Kelley; Sharon Lawlor; Manuel Lombardero; Joan M. MacGregor; Andrew Pelesko; Donna Stoliker; Barbara Walters; Ella Zadorozny

doi:10.1016/j.cgh.2014.06.028

Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

Marc G. Ghany, Robert Perrillo, Ruosha Li, Steven H. Belle, Harry L A Janssen, Norah A. Terrault, Margaret C. Shuhart, Daryl T Y Lau, W. Ray Kim, Michael W. Fried, Richard K. Sterling, Adrian M. Di Bisceglie, Steven Huy B Han, Lilia Milkova Ganova-Raeva, Kyong Mi Chang, Anna Suk Fong Lok, Raymond T. Chung, Lewis R. Roberts, Coleman I. Smith, Mauricio Lisker-MelmanDavid K. Wong, Joshua Juan, Jordan Feld, Colina Yim, Jenny Heathcoate, William M. Lee, Son Do, Tram T. Tran, Mandana Khalili, Stewart L. Cooper, Robert J. Fontana, Naoky Tsai, Keyur Patel, Donna Evon, Robert C. Carithers, Kris V. Kowdley, Chia C. Wang, T. Jake Liang, Jang June Park, Abdus Wahed, David Kleiner, Nezam Afdhal, Asad Javaid, Jianghe Niu, Johanna Han, Imad Nasser, Alisha C. Stahler, Linda Stadheim, Mohamed Hassan, Debra L. King, Rosemary A. Nagy, Danie La, Lucie Liu, Stacey Minshall, Sheila Bass, Samuel French, Velma Peacock, Ashley Ungermann, Claudia Ayala, Emma Olson, Ivy Lau, Veronika Podolskaya, Nata DeVole, Barbara McKenna, Kelly Oberhelman, Sravanthi Kaza, Cassandra Rodd, Leslie Huddleston, Peter Poerzgen, Jama M. Darling, A. Sidney Barritt, Tiffany Marsh, Vikki Metheny, Danielle Cardona, Velimir A. Luketic, Paula G. Smith, Charlotte Hofmann, Terri Mathisen, Susan Strom, Jody Mooney, Lupita Cardona-Gonzalez, Nancy Fryzek, Elenita Rivera, Nevitt Morris, Vanessa Haynes-Williams, Mary E. Valiga, Keith Torrey, Danielle Levine, James Keith, Michael Betts, Luis J. Montaner, Chong Gee Teo, Yury Khudyakov, Lili T. Punkova, Yona Cloonan, Michelle Danielson, Tamara Haller, Geoffrey Johnson, Stephanie Kelley, Sharon Lawlor, Manuel Lombardero, Joan M. MacGregor, Andrew Pelesko, Donna Stoliker, Barbara Walters, Ella Zadorozny

Medicine - Gastro, Hepatology, Nutrition Division

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log₁₀ IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

Original language	English (US)
Pages (from-to)	183-192
Number of pages	10
Journal	Clinical Gastroenterology and Hepatology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.cgh.2014.06.028
State	Published - Jan 1 2015

Bibliographical note

Funding Information:
The HBRN is funded through cooperative U01 grants, with NIDDK officials participating in its design and execution. A Steering Committee composed of the principal investigator of each U01 grant, the principal investigator from the DCC, the principal investigator from the Immunology Center, and the NIDDK project scientist is responsible for study oversight. Several subcommittees have been established to facilitate the work of the Steering Committee ( ). An independent Data and Safety Monitoring Board was appointed by the NIDDK to review the protocols and monitor the progress of the studies and participant safety. Figure 2

Publisher Copyright:
© 2015.

Keywords

ALT
Chronic hepatitis B virus infection
HBeAg
USA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.cgh.2014.06.028

OpenUrl availability

Full text

Cite this

Ghany, M. G., Perrillo, R., Li, R., Belle, S. H., Janssen, H. L. A., Terrault, N. A., Shuhart, M. C., Lau, D. T. Y., Kim, W. R., Fried, M. W., Sterling, R. K., Di Bisceglie, A. M., Han, S. H. B., Ganova-Raeva, L. M., Chang, K. M., Lok, A. S. F., Chung, R. T., Roberts, L. R., Smith, C. I., ... Zadorozny, E. (2015). Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype. Clinical Gastroenterology and Hepatology, 13(1), 183-192. https://doi.org/10.1016/j.cgh.2014.06.028

Ghany, MG, Perrillo, R, Li, R, Belle, SH, Janssen, HLA, Terrault, NA, Shuhart, MC, Lau, DTY, Kim, WR, Fried, MW, Sterling, RK, Di Bisceglie, AM, Han, SHB, Ganova-Raeva, LM, Chang, KM, Lok, ASF, Chung, RT, Roberts, LR, Smith, CI, Lisker-Melman, M, Wong, DK, Juan, J, Feld, J, Yim, C, Heathcoate, J, Lee, WM, Do, S, Tran, TT, Khalili, M, Cooper, SL, Fontana, RJ, Tsai, N, Patel, K, Evon, D, Carithers, RC, Kowdley, KV, Wang, CC, Liang, TJ, Park, JJ, Wahed, A, Kleiner, D, Afdhal, N, Javaid, A, Niu, J, Han, J, Nasser, I, Stahler, AC, Stadheim, L, Hassan, M, King, DL, Nagy, RA, La, D, Liu, L, Minshall, S, Bass, S, French, S, Peacock, V, Ungermann, A, Ayala, C, Olson, E, Lau, I, Podolskaya, V, DeVole, N, McKenna, B, Oberhelman, K, Kaza, S, Rodd, C, Huddleston, L, Poerzgen, P, Darling, JM, Barritt, AS, Marsh, T, Metheny, V, Cardona, D, Luketic, VA, Smith, PG, Hofmann, C, Mathisen, T, Strom, S, Mooney, J, Cardona-Gonzalez, L, Fryzek, N, Rivera, E, Morris, N, Haynes-Williams, V, Valiga, ME, Torrey, K, Levine, D, Keith, J, Betts, M, Montaner, LJ, Teo, CG, Khudyakov, Y, Punkova, LT, Cloonan, Y, Danielson, M, Haller, T, Johnson, G, Kelley, S, Lawlor, S, Lombardero, M, MacGregor, JM, Pelesko, A, Stoliker, D, Walters, B & Zadorozny, E 2015, 'Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype', Clinical Gastroenterology and Hepatology, vol. 13, no. 1, pp. 183-192. https://doi.org/10.1016/j.cgh.2014.06.028

@article{97a5af2a8cf7477a88e5938e9208157d,

title = "Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype",

abstract = "Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.",

keywords = "ALT, Chronic hepatitis B virus infection, HBeAg, USA",

author = "Ghany, {Marc G.} and Robert Perrillo and Ruosha Li and Belle, {Steven H.} and Janssen, {Harry L A} and Terrault, {Norah A.} and Shuhart, {Margaret C.} and Lau, {Daryl T Y} and Kim, {W. Ray} and Fried, {Michael W.} and Sterling, {Richard K.} and {Di Bisceglie}, {Adrian M.} and Han, {Steven Huy B} and Ganova-Raeva, {Lilia Milkova} and Chang, {Kyong Mi} and Lok, {Anna Suk Fong} and Chung, {Raymond T.} and Roberts, {Lewis R.} and Smith, {Coleman I.} and Mauricio Lisker-Melman and Wong, {David K.} and Joshua Juan and Jordan Feld and Colina Yim and Jenny Heathcoate and Lee, {William M.} and Son Do and Tran, {Tram T.} and Mandana Khalili and Cooper, {Stewart L.} and Fontana, {Robert J.} and Naoky Tsai and Keyur Patel and Donna Evon and Carithers, {Robert C.} and Kowdley, {Kris V.} and Wang, {Chia C.} and Liang, {T. Jake} and Park, {Jang June} and Abdus Wahed and David Kleiner and Nezam Afdhal and Asad Javaid and Jianghe Niu and Johanna Han and Imad Nasser and Stahler, {Alisha C.} and Linda Stadheim and Mohamed Hassan and King, {Debra L.} and Nagy, {Rosemary A.} and Danie La and Lucie Liu and Stacey Minshall and Sheila Bass and Samuel French and Velma Peacock and Ashley Ungermann and Claudia Ayala and Emma Olson and Ivy Lau and Veronika Podolskaya and Nata DeVole and Barbara McKenna and Kelly Oberhelman and Sravanthi Kaza and Cassandra Rodd and Leslie Huddleston and Peter Poerzgen and Darling, {Jama M.} and Barritt, {A. Sidney} and Tiffany Marsh and Vikki Metheny and Danielle Cardona and Luketic, {Velimir A.} and Smith, {Paula G.} and Charlotte Hofmann and Terri Mathisen and Susan Strom and Jody Mooney and Lupita Cardona-Gonzalez and Nancy Fryzek and Elenita Rivera and Nevitt Morris and Vanessa Haynes-Williams and Valiga, {Mary E.} and Keith Torrey and Danielle Levine and James Keith and Michael Betts and Montaner, {Luis J.} and Teo, {Chong Gee} and Yury Khudyakov and Punkova, {Lili T.} and Yona Cloonan and Michelle Danielson and Tamara Haller and Geoffrey Johnson and Stephanie Kelley and Sharon Lawlor and Manuel Lombardero and MacGregor, {Joan M.} and Andrew Pelesko and Donna Stoliker and Barbara Walters and Ella Zadorozny",

note = "Funding Information: The HBRN is funded through cooperative U01 grants, with NIDDK officials participating in its design and execution. A Steering Committee composed of the principal investigator of each U01 grant, the principal investigator from the DCC, the principal investigator from the Immunology Center, and the NIDDK project scientist is responsible for study oversight. Several subcommittees have been established to facilitate the work of the Steering Committee ( ). An independent Data and Safety Monitoring Board was appointed by the NIDDK to review the protocols and monitor the progress of the studies and participant safety. Figure 2 Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.cgh.2014.06.028",

language = "English (US)",

volume = "13",

pages = "183--192",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

AU - Ghany, Marc G.

AU - Perrillo, Robert

AU - Li, Ruosha

AU - Belle, Steven H.

AU - Janssen, Harry L A

AU - Terrault, Norah A.

AU - Shuhart, Margaret C.

AU - Lau, Daryl T Y

AU - Kim, W. Ray

AU - Fried, Michael W.

AU - Sterling, Richard K.

AU - Di Bisceglie, Adrian M.

AU - Han, Steven Huy B

AU - Ganova-Raeva, Lilia Milkova

AU - Chang, Kyong Mi

AU - Lok, Anna Suk Fong

AU - Chung, Raymond T.

AU - Roberts, Lewis R.

AU - Smith, Coleman I.

AU - Lisker-Melman, Mauricio

AU - Wong, David K.

AU - Juan, Joshua

AU - Feld, Jordan

AU - Yim, Colina

AU - Heathcoate, Jenny

AU - Lee, William M.

AU - Do, Son

AU - Tran, Tram T.

AU - Khalili, Mandana

AU - Cooper, Stewart L.

AU - Fontana, Robert J.

AU - Tsai, Naoky

AU - Patel, Keyur

AU - Evon, Donna

AU - Carithers, Robert C.

AU - Kowdley, Kris V.

AU - Wang, Chia C.

AU - Liang, T. Jake

AU - Park, Jang June

AU - Wahed, Abdus

AU - Kleiner, David

AU - Afdhal, Nezam

AU - Javaid, Asad

AU - Niu, Jianghe

AU - Han, Johanna

AU - Nasser, Imad

AU - Stahler, Alisha C.

AU - Stadheim, Linda

AU - Hassan, Mohamed

AU - King, Debra L.

AU - Nagy, Rosemary A.

AU - La, Danie

AU - Liu, Lucie

AU - Minshall, Stacey

AU - Bass, Sheila

AU - French, Samuel

AU - Peacock, Velma

AU - Ungermann, Ashley

AU - Ayala, Claudia

AU - Olson, Emma

AU - Lau, Ivy

AU - Podolskaya, Veronika

AU - DeVole, Nata

AU - McKenna, Barbara

AU - Oberhelman, Kelly

AU - Kaza, Sravanthi

AU - Rodd, Cassandra

AU - Huddleston, Leslie

AU - Poerzgen, Peter

AU - Darling, Jama M.

AU - Barritt, A. Sidney

AU - Marsh, Tiffany

AU - Metheny, Vikki

AU - Cardona, Danielle

AU - Luketic, Velimir A.

AU - Smith, Paula G.

AU - Hofmann, Charlotte

AU - Mathisen, Terri

AU - Strom, Susan

AU - Mooney, Jody

AU - Cardona-Gonzalez, Lupita

AU - Fryzek, Nancy

AU - Rivera, Elenita

AU - Morris, Nevitt

AU - Haynes-Williams, Vanessa

AU - Valiga, Mary E.

AU - Torrey, Keith

AU - Levine, Danielle

AU - Keith, James

AU - Betts, Michael

AU - Montaner, Luis J.

AU - Teo, Chong Gee

AU - Khudyakov, Yury

AU - Punkova, Lili T.

AU - Cloonan, Yona

AU - Danielson, Michelle

AU - Haller, Tamara

AU - Johnson, Geoffrey

AU - Kelley, Stephanie

AU - Lawlor, Sharon

AU - Lombardero, Manuel

AU - MacGregor, Joan M.

AU - Pelesko, Andrew

AU - Stoliker, Donna

AU - Walters, Barbara

AU - Zadorozny, Ella

N1 - Funding Information: The HBRN is funded through cooperative U01 grants, with NIDDK officials participating in its design and execution. A Steering Committee composed of the principal investigator of each U01 grant, the principal investigator from the DCC, the principal investigator from the Immunology Center, and the NIDDK project scientist is responsible for study oversight. Several subcommittees have been established to facilitate the work of the Steering Committee ( ). An independent Data and Safety Monitoring Board was appointed by the NIDDK to review the protocols and monitor the progress of the studies and participant safety. Figure 2 Publisher Copyright: © 2015.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

AB - Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

KW - ALT

KW - Chronic hepatitis B virus infection

KW - HBeAg

KW - USA

UR - http://www.scopus.com/inward/record.url?scp=84916910477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916910477&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2014.06.028

DO - 10.1016/j.cgh.2014.06.028

M3 - Article

C2 - 25010003

AN - SCOPUS:84916910477

SN - 1542-3565

VL - 13

SP - 183

EP - 192

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 1

ER -

Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this