Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)

Stephen R. Mascioli, Richard H. Grimm, James D. Neaton, Jeremiah Stamler, Ronald J. Prineas, Jeffrey A. Cutler, Patricia J. Elmer, Robert McDonald, Harold Schnaper, James Schoenberger

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.

Original languageEnglish (US)
Pages (from-to)C32-C35
JournalThe American Journal of Cardiology
Volume66
Issue number9
DOIs
StatePublished - Sep 25 1990

Bibliographical note

Funding Information:
From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota. This study is being supported in part by a grant from the National Heart, Lung, and Blood Institute, Beth&a, Maryland, and grants from Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp and Dohme, Pfizer Pharmaceuticals. and Wyeth-Aycrst Laboratories.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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