Characterization of Image-based Refocusing for Transcranial Therapies

P. D. O'Brien, Collin S. Smith, Hasan Aldiabat, Dalong Liu, Rajagopal N. Aravalli, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Transcranial focused ultrasound (tFUS) has the potential to provide precision ultrasonic targeting of brain circuits in the treatment neurological disorders. However, this potential is severely limited by FUS beam distortions through the skull. We have previously demonstrated the feasibility of using dual-mode ultrasound array (DMUA) capabilities to perform refocusing based on target identification on DMUA imaging. Furthermore, we have demonstrated improved refocusing when the target echoes are sufficiently coherent, as measured using a focusing data matrix (FDM) evaluated from raw channel data. The objective of this study is to characterize this geometric refocusing-aberration correction method and extend its use. Specifically, refocusing off of coherent echoes in the vicinity of the intended target as identified on DMUA imaging. In vitro transskull experiments were performed with sample skulls placed in the path of DMUA focused beams. Beam distortions were characterized using 2D hydrophone scans in planes orthogonal to the FUS beam axis before and after refocusing. The results provide experimental verification of the improved focusing gain achieved when refocusing at the target or points in its vicinity. The improvement was in the range of 3 7 dB for a variety of target locations with respect to the skull-suture lines.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages456-459
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/TerritoryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

Bibliographical note

Funding Information:
Funded by Grant NS098781 from the National Institute of Health

Publisher Copyright:
© 2019 IEEE.

Keywords

  • Focusing Data Matrix
  • Refocusing
  • Transcranial FUS

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