The association of interstitial nephritis, the most common renal lesion in Sjogren's syndrome, to the other manifestations of the disease is unclear. To begin to address this issue, the infiltrating cells in frozen kidney tissues from two patients with interstitial nephritis secondary to Sjogren's syndrome were characterized by indirect immunofluorescence. T cells predominated, the majority of which were helper/inducer cells (OKT4+). Both kidneys contained nodules of B cells. The increased proportion of OKT4+ T cells in salivary gland and in interstitial renal lesions of Sjogren's syndrome contrasts with some other forms of interstitial renal disease and suggests that the renal and salivary gland lesions have a similar pathogeneis.
Bibliographical noteFunding Information:
From the Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis; and Wilford Hall Medical Center, Lackland Air Force Base, TX. Supported by grants from the National Institutes of Health (AM25518) and the American Heart Association. Dr Rosenberg is under tenure of a MRC Fellowship, and Dr Platt, an AHA Clinician-Scientist Award. Address reprint requests to Mark E. Rosenberg, MD, University of Minnesota, Box 736 UMHC, 516 Delaware Street Southeast, Minneapolis, MN 55455. © 1988 by the National Kidney Foundation, Inc. 0272-6386/88/1 101-0004$3.00/0
- Sjogren's syndrome
- interstitial nephritis