Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets

The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.