Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome

Arthur N. Mayeno, Feng Lin, Christopher S. Foote, David A. Loegering, Matthew M. Ames, Craig W. Hedberg, Gerald J. Gleich

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan Nα-aminal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1′-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.

Original languageEnglish (US)
Pages (from-to)1707-1708
Number of pages2
JournalScience
Volume250
Issue number4988
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Dive into the research topics of 'Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome'. Together they form a unique fingerprint.

Cite this