Abstract
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan Nα-aminal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1′-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.
Original language | English (US) |
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Pages (from-to) | 1707-1708 |
Number of pages | 2 |
Journal | Science |
Volume | 250 |
Issue number | 4988 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |