TY - JOUR
T1 - Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities
AU - Sreevatsan, Srinand
AU - Pan, Xi
AU - Stockbauer, Kathryn E.
AU - Williams, Diana L.
AU - Kreiswirth, Barry N.
AU - Musser, James M.
PY - 1996/4
Y1 - 1996/4
N2 - Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the 78 resistant organisms had missense mutations in codon 43 of rpsL resulting in a K-43→R substitution. Mutations in codon 88 of rpsL were also identified in four Asian isolates.
AB - Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the 78 resistant organisms had missense mutations in codon 43 of rpsL resulting in a K-43→R substitution. Mutations in codon 88 of rpsL were also identified in four Asian isolates.
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U2 - 10.1128/aac.40.4.1024
DO - 10.1128/aac.40.4.1024
M3 - Comment/debate
C2 - 8849220
AN - SCOPUS:0029978270
SN - 0066-4804
VL - 40
SP - 1024
EP - 1026
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
ER -