Abstract
Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.
Original language | English (US) |
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Pages (from-to) | 1193-1197 |
Number of pages | 5 |
Journal | Neuroreport |
Volume | 19 |
Issue number | 12 |
DOIs | |
State | Published - Aug 6 2008 |
Keywords
- Calcium
- Calsenilin/DREAM/KChIP3
- Subcellular localization