Characterization of the Yoshida sarcoma: A model of cancer cachexia

Mary Ann Honors; Kimberly P. Kinzig

doi:10.1007/s00520-013-1839-y

Characterization of the Yoshida sarcoma: A model of cancer cachexia

Mary Ann Honors, Kimberly P. Kinzig

Epidemiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: Cancer cachexia contributes significantly to morbidity and mortality in individuals with cancer. Currently, the mechanisms contributing to the development of cachexia are largely unknown, leading to a paucity of treatment and prevention options. Animal models are necessary in determining causal mechanisms and in testing potential treatments. While the Yoshida sarcoma has been utilized for more than 50 years, the cachexia syndrome produced by this model has not been well characterized in the literature. Methods: Tumor allografts were subcutaneously implanted in male Sprague Dawley rats (n = 16) and allowed to grow for 23 days. Control animals (n = 16) received a sham surgery. All rats were monitored daily for the presence of hallmark cachexia symptoms. Results: The results demonstrate the presence of decreased body weight gain, as well as lower levels of body adiposity and skeletal muscle mass, in tumor-bearing animals, as compared to controls. Conclusions: While a large tumor burden was reached, the extent of cachexia was similar to that which is observed in many individuals with cancer cachexia. Future experiments utilizing this model are encouraged to identify mechanisms and effective treatment and prevention strategies.

Original language	English (US)
Pages (from-to)	2687-2694
Number of pages	8
Journal	Supportive Care in Cancer
Volume	21
Issue number	10
DOIs	https://doi.org/10.1007/s00520-013-1839-y
State	Published - Oct 2013

Bibliographical note

Funding Information:
Acknowledgments The authors would like to acknowledge the contributions of Meredith Cobb and Melissa McCurley (for technical assistance), and Dr. Terry Powley, Dr. Terry Davidson, and Dr. Jim Fleet (for editorial comments and suggestions). This work was supported by National Institutes of Health DK078654 (KPK) and by the National Institutes of Health, National Cancer Institute R25CA128770 (D. Teegarden) Cancer Prevention Internship Program administered by the Oncological Sciences Center and the Discovery Learning Research Center at Purdue University (MAH).

Keywords

Animals models
Cancer cachexia
Yoshida sarcoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Purpose: Cancer cachexia contributes significantly to morbidity and mortality in individuals with cancer. Currently, the mechanisms contributing to the development of cachexia are largely unknown, leading to a paucity of treatment and prevention options. Animal models are necessary in determining causal mechanisms and in testing potential treatments. While the Yoshida sarcoma has been utilized for more than 50 years, the cachexia syndrome produced by this model has not been well characterized in the literature. Methods: Tumor allografts were subcutaneously implanted in male Sprague Dawley rats (n = 16) and allowed to grow for 23 days. Control animals (n = 16) received a sham surgery. All rats were monitored daily for the presence of hallmark cachexia symptoms. Results: The results demonstrate the presence of decreased body weight gain, as well as lower levels of body adiposity and skeletal muscle mass, in tumor-bearing animals, as compared to controls. Conclusions: While a large tumor burden was reached, the extent of cachexia was similar to that which is observed in many individuals with cancer cachexia. Future experiments utilizing this model are encouraged to identify mechanisms and effective treatment and prevention strategies.",

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Characterization of the Yoshida sarcoma: A model of cancer cachexia

Abstract

Bibliographical note

Keywords

UN SDGs

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