Chemical constituents from the whole herb of Hemiphragma heterophyllum

Jia Meng Dai, Yan Hong Li, Xiao Yun Pu, Cui Yang, Jing Xian Sun, Roger Ruan, Xiao Nian Li, Kai Tian, Xiang Zhong Huang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalJournal of Asian Natural Products Research
Volume21
Issue number6
DOIs
StatePublished - Jun 3 2019
Externally publishedYes

Bibliographical note

Funding Information:
This work was financially supported by the NSFC [grant number 81460535], the Natural Science Foundation of Yunnan Province [grant number Y0120160159], the Yunnan Provincial Department of Education Science Research Fund Project [grant number 2017YJS058], and the Yunnan Provincial Applied Basic Research Projects [grant number 2017FD122].

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Hemiphragma heterophyllum
  • Scrophulariaceae
  • iridoids
  • sesquineolignans
  • α-glucosidase inhibitory activity

Fingerprint

Dive into the research topics of 'Chemical constituents from the whole herb of Hemiphragma heterophyllum'. Together they form a unique fingerprint.

Cite this