Chemical constituents from the whole herb of Hemiphragma heterophyllum

Jia Meng Dai, Yan Hong Li, Xiao Yun Pu, Cui Yang, Jing Xian Sun, Roger Ruan, Xiao Nian Li, Kai Tian, Xiang Zhong Huang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalJournal of Asian Natural Products Research
Issue number6
StatePublished - Jun 3 2019
Externally publishedYes


  • Hemiphragma heterophyllum
  • Scrophulariaceae
  • iridoids
  • sesquineolignans
  • α-glucosidase inhibitory activity

PubMed: MeSH publication types

  • Journal Article

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