Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery

Hyun Su Min, Sejin Son, Dong Gil You, Tae Woong Lee, Jangwook Lee, Sangmin Lee, Ji Young Yhee, Jaeyoung Lee, Moon Hee Han, Jae Hyung Park, Sun Hwa Kim, Kuiwon Choi, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Although there is great versatility of ultrasound (US) technologies in the real clinical field, one main technical challenge is the compromising of high quality of echo properties and size engineering of ultrasound contrast agents (UCAs); a high echo property is offset by reducing particle size. Herein, a new strategy for overcoming the dilemma by devising chemical gas (CO2) generating carbonate copolymer nanoparticles (Gas-NPs), which are clearly distinguished from the conventional gas-encapsulated micro-sized UCAs. More importantly, Gas-NPs could be readily engineered to strengthen the desirable in vivo physicochemical properties for nano-sized drug carriers with higher tumor targeting ability, as well as the high quality of echo properties for tumor-targeted US imaging. In tumor-bearing mice, anticancer drug-loaded Gas-NPs showed the desirable theranostic functions for US-triggered drug delivery, even after i.v. injection. In this regard, and as demonstrated in the aforementioned study, our technology could serve a highly effective platform in building theranostic UCAs with great sophistication and therapeutic applicability in tumor-targeted US imaging and US-triggered drug delivery.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalBiomaterials
Volume108
DOIs
StatePublished - Nov 1 2016

Bibliographical note

Funding Information:
This work was financially supported by the GRL Project ( NRF-2013K1A1A2A02050115 ), the GiRC ( NRF 2012K1A1A2A01055811 ), and the Intramural Research Program of KIST (CATS project).

Keywords

  • Chemical gas-generating nanoparticle
  • Drug delivery
  • Tumor targeting
  • Ultrasound (US) imaging
  • Ultrasound contrast agent (UCA)

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