Chemical Tools to Monitor and Manipulate Adaptive Immune Responses

Todd M. Doran, Mohosin Sarkar, Thomas Kodadek

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Methods to monitor and manipulate the immune system are of enormous clinical interest. For example, the development of vaccines represents one of the earliest and greatest accomplishments of the biomedical research enterprise. More recently, drugs capable of "reawakening" the immune system to cancer have generated enormous excitement. But, much remains to be done. All drugs available today that manipulate the immune system cannot distinguish between "good" and "bad" immune responses and thus drive general and systemic immune suppression or activation. Indeed, with the notable exception of vaccines, our ability to monitor and manipulate antigen-specific immune responses is in its infancy. Achieving this finer level of control would be highly desirable. For example, it might allow the pharmacological editing of pathogenic immune responses without restricting the ability of the immune system to defend against infection. On the diagnostic side, a method to comprehensively monitor the circulating, antigen-specific antibody population could provide a treasure trove of clinically useful biomarkers, since many diseases expose the immune system to characteristic molecules that are deemed foreign and elicit the production of antibodies against them. This Perspective will discuss the state-of-the-art of this area with a focus on what we consider seminal opportunities for the chemistry community to contribute to this important field.

Original languageEnglish (US)
Pages (from-to)6076-6094
Number of pages19
JournalJournal of the American Chemical Society
Volume138
Issue number19
DOIs
StatePublished - May 18 2016

Fingerprint Dive into the research topics of 'Chemical Tools to Monitor and Manipulate Adaptive Immune Responses'. Together they form a unique fingerprint.

Cite this