TY - JOUR
T1 - Chemistry and biochemistry of the neomycins. XVI
T2 - Nthesis and bioactivity of hexa-n-benzylneomycins
AU - Shier, Thomas
AU - Rinehart, Kenneth L.
PY - 1973
Y1 - 1973
N2 - Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.
AB - Hexa-N-benzylneomycin and five analogs substituted on the phenyl ring have been prepared by reductive alkylation of neomycin with the appropriate benzaldehydes. Most of the six show activity, to varying degrees, against a number of microorganisms, including Staphylococcus aureus, in vitro. Little or no activity was evidenced in vivo against Staphylococcus aureus, however.
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U2 - 10.7164/antibiotics.26.547
DO - 10.7164/antibiotics.26.547
M3 - Article
C2 - 4151940
AN - SCOPUS:0015862491
SN - 0021-8820
VL - 26
SP - 547
EP - 550
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 10
ER -
