Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.

Original languageEnglish (US)
Pages (from-to)476-488
Number of pages13
JournalNature Reviews Cancer
Volume9
Issue number7
DOIs
StatePublished - Jul 2009

Bibliographical note

Funding Information:
The authors’ research on chemoprevention of lung carcinogenesis is supported in part by grants number CA-81301, CA-102502, CA-128801 and DA-13333 from the US National Institutes of Health and grant number RP-00-138 from the American Cancer Society. We thank B. Carlson for outstanding assistance in the preparation of this manuscript.

Fingerprint Dive into the research topics of 'Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers'. Together they form a unique fingerprint.

Cite this