Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.
Bibliographical noteFunding Information:
The authors’ research on chemoprevention of lung carcinogenesis is supported in part by grants number CA-81301, CA-102502, CA-128801 and DA-13333 from the US National Institutes of Health and grant number RP-00-138 from the American Cancer Society. We thank B. Carlson for outstanding assistance in the preparation of this manuscript.