TY - JOUR
T1 - Chemotherapy With cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) for hodgkin disease
T2 - Fourteen‐year follow‐up results
AU - Dusenbery, Kathryn E
AU - Peterson, Bruce A
AU - Bloomfield, Clara D.
PY - 1988/8
Y1 - 1988/8
N2 - Thirty‐eight patients with advanced Hodgkin disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) from 1970 to 1973 and followed prospectively. Long‐term results after a median follow‐up of 14 years are reported. Seventeen of the 28 complete responders (61%) survived more than 10 years from the initiation of chemotherapy. At the current time, 12 of the 28 patients (43%) are continuously disease‐free 12.8 to 15.3 years after completing induction chemotherapy. Two additional patients are alive in third and fifth remissions. All relapses occurred within 5.5 years of completing induction chemotherapy. Late complications included sterility, aseptic osteonecrosis, severe pulmonary fibrosis, and chronic uveitis. Four of the complete responders (14%) developed second neoplasms, including acute myelogenous leukemia, non‐Hodgkin lymphoma and small cell carcinoma of the lung. All second malignancies were fatal and developed 5‐13 years after initiation of induction chemotherapy. Our data confirm that cure is possible with alternative regimens to MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone).
AB - Thirty‐eight patients with advanced Hodgkin disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) from 1970 to 1973 and followed prospectively. Long‐term results after a median follow‐up of 14 years are reported. Seventeen of the 28 complete responders (61%) survived more than 10 years from the initiation of chemotherapy. At the current time, 12 of the 28 patients (43%) are continuously disease‐free 12.8 to 15.3 years after completing induction chemotherapy. Two additional patients are alive in third and fifth remissions. All relapses occurred within 5.5 years of completing induction chemotherapy. Late complications included sterility, aseptic osteonecrosis, severe pulmonary fibrosis, and chronic uveitis. Four of the complete responders (14%) developed second neoplasms, including acute myelogenous leukemia, non‐Hodgkin lymphoma and small cell carcinoma of the lung. All second malignancies were fatal and developed 5‐13 years after initiation of induction chemotherapy. Our data confirm that cure is possible with alternative regimens to MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone).
KW - combination chemotherapy
KW - complications
KW - cure
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U2 - 10.1002/ajh.2830280407
DO - 10.1002/ajh.2830280407
M3 - Article
C2 - 3414672
AN - SCOPUS:0023814676
SN - 0361-8609
VL - 28
SP - 246
EP - 251
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 4
ER -