Childhood cancer following neonatal oxygen supplementation

Logan G. Spector; Mark A. Klebanoff; James H. Feusner; Michael K. Georgieff; Julie A. Ross

doi:10.1016/j.jpeds.2005.03.008

Childhood cancer following neonatal oxygen supplementation

Logan G. Spector, Mark A. Klebanoff, James H. Feusner, Michael K. Georgieff, Julie A. Ross

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Objective: To evaluate the relationship between neonatal oxygen supplementation (O₂) and childhood cancer in the Collaborative Perinatal Project (CPP). Study design: The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O ₂ and cancer (n = 48). Results: The hazard ratio (HR) for any O ₂ was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O₂ was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O₂, respectively, to no O₂. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant (P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41). Conclusions: These findings are consistent with an association between O₂ for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study.

Original language	English (US)
Pages (from-to)	27-31
Number of pages	5
Journal	Journal of Pediatrics
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/j.jpeds.2005.03.008
State	Published - Jul 2005

Bibliographical note

Funding Information:
Supported by the University of Minnesota Children's Cancer Research Fund.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.jpeds.2005.03.008

OpenUrl availability

Full text

Cite this

@article{6da65274922b471fbe0d3d316ce54009,

title = "Childhood cancer following neonatal oxygen supplementation",

abstract = "Objective: To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP). Study design: The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O 2 and cancer (n = 48). Results: The hazard ratio (HR) for any O 2 was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O2 was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O2, respectively, to no O2. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant (P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41). Conclusions: These findings are consistent with an association between O2 for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study.",

author = "Spector, {Logan G.} and Klebanoff, {Mark A.} and Feusner, {James H.} and Georgieff, {Michael K.} and Ross, {Julie A.}",

note = "Funding Information: Supported by the University of Minnesota Children's Cancer Research Fund. ",

year = "2005",

month = jul,

doi = "10.1016/j.jpeds.2005.03.008",

language = "English (US)",

volume = "147",

pages = "27--31",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Childhood cancer following neonatal oxygen supplementation

AU - Spector, Logan G.

AU - Klebanoff, Mark A.

AU - Feusner, James H.

AU - Georgieff, Michael K.

AU - Ross, Julie A.

N1 - Funding Information: Supported by the University of Minnesota Children's Cancer Research Fund.

PY - 2005/7

Y1 - 2005/7

N2 - Objective: To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP). Study design: The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O 2 and cancer (n = 48). Results: The hazard ratio (HR) for any O 2 was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O2 was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O2, respectively, to no O2. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant (P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41). Conclusions: These findings are consistent with an association between O2 for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study.

AB - Objective: To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP). Study design: The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O 2 and cancer (n = 48). Results: The hazard ratio (HR) for any O 2 was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O2 was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O2, respectively, to no O2. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant (P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41). Conclusions: These findings are consistent with an association between O2 for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study.

UR - http://www.scopus.com/inward/record.url?scp=22144487757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144487757&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2005.03.008

DO - 10.1016/j.jpeds.2005.03.008

M3 - Article

C2 - 16027689

AN - SCOPUS:22144487757

SN - 0022-3476

VL - 147

SP - 27

EP - 31

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 1

ER -

Childhood cancer following neonatal oxygen supplementation

Abstract

Bibliographical note

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this