Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics

Daniel J. Garry, Arthur L. Caplan, Mary G. Garry

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.

Original languageEnglish (US)
Pages (from-to)538-540
Number of pages3
JournalStem Cell Reports
Volume14
Issue number4
DOIs
StatePublished - Apr 14 2020

Bibliographical note

Funding Information:
D.J.G. is supported by grants from RMM, DOD, and the Lillehei Family Foundation. M.G.G. is supported by grant funding from the DOD. D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest.

Funding Information:
D.J.G. is supported by grants from RMM , DOD , and the Lillehei Family Foundation . M.G.G. is supported by grant funding from the DOD . D.J.G. and M.G.G. are co-founders of NorthStar Genomics. A.L.C. has no conflicts of interest.

Publisher Copyright:
© 2020 The Authors

Keywords

  • Etv2
  • chimeras
  • complementation
  • ethics
  • human
  • pig

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