Chloroquine Reduces Neuronal and Glial Iron Uptake

Kenneth F Swaiman; Valynda L. Machen

doi:10.1111/j.1471-4159.1986.tb13017.x

Chloroquine Reduces Neuronal and Glial Iron Uptake

Kenneth F Swaiman, Valynda L. Machen

Neurology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Abstract: The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin‐iron complex.

Original language	English (US)
Pages (from-to)	652-654
Number of pages	3
Journal	Journal of Neurochemistry
Volume	46
Issue number	2
DOIs	https://doi.org/10.1111/j.1471-4159.1986.tb13017.x
State	Published - Feb 1986

Keywords

Chloroquine
Glia
Iron uptake
Neurons

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abstract = "Abstract: The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin‐iron complex.",

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AU - Machen, Valynda L.

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N2 - Abstract: The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin‐iron complex.

AB - Abstract: The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin‐iron complex.

KW - Chloroquine

KW - Glia

KW - Iron uptake

KW - Neurons

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Chloroquine Reduces Neuronal and Glial Iron Uptake

Abstract

Keywords

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