Chloroquine Reduces Neuronal and Glial Iron Uptake

Kenneth F Swaiman, Valynda L. Machen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Abstract: The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin‐iron complex.

Original languageEnglish (US)
Pages (from-to)652-654
Number of pages3
JournalJournal of Neurochemistry
Volume46
Issue number2
DOIs
StatePublished - Feb 1986

Keywords

  • Chloroquine
  • Glia
  • Iron uptake
  • Neurons

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