“CHOICES”: An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy

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Abstract

Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. Material and Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. Result/Discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Conclusion: The “CHOICES” acronym delineates various toxic etiologies of ATL.

Original languageEnglish (US)
Pages (from-to)243-257
Number of pages15
JournalEuropean Journal of Radiology Open
Volume6
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Acute toxic leukoencephalopathy
  • Diffusion-Weighted imaging
  • Periventricular white matter

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