Cholesterol pool sizes and turnover following portacaval shunt in the dog

J. J. Coyle, I. J. Guzman, R. L. Varco, Henry Buchwald

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Portacaval shunt has been shown to be effective in lowering the plasma cholesterol level of both man and experimental animal. However, the primary mechanism which effects this reduction is unclear. The authors have measured the rapidly, and the slowly, miscible cholesterol pool sizes and the cholesterol production rate in mongrel dogs, with the animals in the cholesterol steady state, using 14C-cholesterol plasma decay curve analysis. Five control animals and 3 one-yr postoperative portacaval shunt animals with a 50% plasma cholesterol level reduction were studied. No differences were demonstrated in either the cholesterol pool sizes or the production rate. These data have led the authors to postulate 2 hypotheses to explain the mechanism of the hypocholesterolemic effect of the portacaval shunt.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalSurgery Gynecology and Obstetrics
Issue number5
StatePublished - Dec 1 1979


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