Portacaval shunt has been shown to be effective in lowering the plasma cholesterol level of both man and experimental animal. However, the primary mechanism which effects this reduction is unclear. The authors have measured the rapidly, and the slowly, miscible cholesterol pool sizes and the cholesterol production rate in mongrel dogs, with the animals in the cholesterol steady state, using 14C-cholesterol plasma decay curve analysis. Five control animals and 3 one-yr postoperative portacaval shunt animals with a 50% plasma cholesterol level reduction were studied. No differences were demonstrated in either the cholesterol pool sizes or the production rate. These data have led the authors to postulate 2 hypotheses to explain the mechanism of the hypocholesterolemic effect of the portacaval shunt.
|Original language||English (US)|
|Number of pages||5|
|Journal||Surgery Gynecology and Obstetrics|
|State||Published - Dec 1 1979|