Cholesterol synthesis inhibitors inhibit more than cholesterol synthesis

B. L. Kasiske, M. P. O'Donnell, Y. Kim, D. Atluru, W. F. Keane

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The beneficial effects of HMG-CoA reductase inhibition in models of progressive glomerular injury may not all be due to reductions in circulating lipoproteins and decreases in glomerular lipoprotein deposition. Indeed, HMG-CoA reductase inhibitors may have direct effects on glomerular mesangial cells that could explain the amelioration of renal injury. Specifically, HMG-CoA reductase inhibitors block the synthesis of isoprenoids that are necessary for mesangial cell proliferation and other important cell functions. Thus, protein isoprenylation may play a critical role in the pathogenesis and treatment of lipid-induced glomerular injury.

Original languageEnglish (US)
Pages (from-to)S-51-S-53
JournalKidney International, Supplement
Issue number45
StatePublished - Jan 1 1994

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