TY - JOUR
T1 - Chorea as an unusual presenting feature of Anti-Phospholipid syndrome
AU - Ishaq, Saliha
AU - Khalil, Sarwat
AU - Khan, Ayesha
AU - Khalid, Umair
PY - 2010/11
Y1 - 2010/11
N2 - Anti-Phospholipid Syndrome (APS) can manifest as primary disease or secondary to connective tissue diseases, such as Systemic Lupus Erythematosus (SLE). It is characterized by recurrent arterial or venous thrombosis, thrombocytopenia, haemolytic anaemia, or positive Coombs' test, and recurrent pregnancy loss in females. Common neurological abnormalities include stroke, cognitive deficits and white matter lesions. We present an unusual case of secondary APS associated with SLE, that presented at our clinic with chorea. To the best of our knowledge this is a first such case reported from Pakistan. APS must be ruled out in any patient of SLE who presents with stroke or any other neurological abnormality regardless of the age at presentation. Moreover, unusual neurological presentations, such as chorea, should always be kept in mind in order to promptly diagnose and treat APS owing to its high morbidity and mortality.
AB - Anti-Phospholipid Syndrome (APS) can manifest as primary disease or secondary to connective tissue diseases, such as Systemic Lupus Erythematosus (SLE). It is characterized by recurrent arterial or venous thrombosis, thrombocytopenia, haemolytic anaemia, or positive Coombs' test, and recurrent pregnancy loss in females. Common neurological abnormalities include stroke, cognitive deficits and white matter lesions. We present an unusual case of secondary APS associated with SLE, that presented at our clinic with chorea. To the best of our knowledge this is a first such case reported from Pakistan. APS must be ruled out in any patient of SLE who presents with stroke or any other neurological abnormality regardless of the age at presentation. Moreover, unusual neurological presentations, such as chorea, should always be kept in mind in order to promptly diagnose and treat APS owing to its high morbidity and mortality.
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M3 - Article
C2 - 21375211
AN - SCOPUS:78149269833
SN - 0030-9982
VL - 60
SP - 975
EP - 976
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 11
ER -