Chromosome cohesion and the spindle checkpoint

Laura A. Díaz-Martínez, Duncan J. Clarke

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Accurate chromosome segregation constitutes the basis of inheritance. Mistakes in chromosome segregation during mitosis lead to aneuploidy, a common feature of tumors. The accuracy of chromosome segregation is governed by a complex network of processes which ensure that each daughter cell receives the correct number of chromosomes. Herein we review recent developments in the understanding of chromosome segregation, focusing on the cohesion that holds the sister chromatids together and the spindle checkpoint which regulates anaphase onset.

Original languageEnglish (US)
Pages (from-to)2733-2740
Number of pages8
JournalCell Cycle
Volume8
Issue number17
DOIs
StatePublished - Sep 1 2009

Keywords

  • Cohesin
  • Mcd1
  • Mitosis
  • Rad21
  • Scc1
  • Spindle checkpoint
  • cdc20

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