Chromosome size in diploid eukaryotic species centers on the average length with a conserved boundary

Xianran Li, Chengsong Zhu, Zhongwei Lin, Yun Wu, Dabao Zhang, Guihua Bai, Weixing Song, Jianxin Ma, Gary J. Muehlbauer, Michael J. Scanlon, Min Zhang, Jianming Yu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Understanding genome and chromosome evolution is important for understanding genetic inheritance and evolution. Universal events comprising DNA replication, transcription, repair, mobile genetic element transposition, chromosome rearrangements, mitosis, and meiosis underlie inheritance and variation of living organisms. Although the genome of a species as a whole is important, chromosomes are the basic units subjected to genetic events that coin evolution to a large extent. Now many complete genome sequences are available, we can address evolution and variation of individual chromosomes across species. For example, "How are the repeat and nonrepeat proportions of genetic codes distributed among different chromosomes in a multichromosome species?" "Is there a general rule behind the intuitive observation that chromosome lengths tend to be similar in a species, and if so, can we generalize any findings in chromosome content and size across different taxonomic groups?" Here, we show that chromosomes within a species do not show dramatic fluctuation in their content of mobile genetic elements as the proliferation of these elements increases from unicellular eukaryotes to vertebrates. Furthermore, we demonstrate that, notwithstanding the remarkable plasticity, there is an upper limit to chromosome-size variation in diploid eukaryotes with linear chromosomes. Strikingly, variation in chromosome size for 886 chromosomes in 68 eukaryotic genomes (including 22 human autosomes) can be viably captured by a single model, which predicts that the vast majority of the chromosomes in a species are expected to have a base pair length between 0.4035 and 1.8626 times the average chromosome length. This conserved boundary of chromosome-size variation, which prevails across a wide taxonomic range with few exceptions, indicates that cellular, molecular, and evolutionary mechanisms, possibly together, confine the chromosome lengths around a species-specific average chromosome length.

Original languageEnglish (US)
Pages (from-to)1901-1911
Number of pages11
JournalMolecular biology and evolution
Volume28
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • chromosome size
  • evolutionary modeling
  • genome evolution

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