Chronic kidney disease is an independent predictor of pocket hematoma after pacemaker and defibrillator implantation

Imdad Ahmed, Elie Gertner, William B. Nelson, Chad M. House, Dennis W Zhu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Introduction: The aim of this investigation was to determine additional predisposing factors of pocket hematoma formation in patients undergoing anti-arrhythmic device surgery. Methods: Initially, we performed a retrospective chart review of 459 patients on warfarin therapy who underwent anti-arrhythmic device surgery (pacemaker or defibrillator implantation, generator replacement, or lead revision) between April 2004 and September 2008 to determine whether continuation of anticoagulation or cessation of anticoagulation, with or without bridging therapy, was the preferred approach. In those patients who developed pocket hematoma, we then analyzed factors that might predispose to hematoma formation. Results: The incidence of pocket hematoma in the entire group was 2.2% (n=10). Forty-eight percent of the patient group was on continued warfarin (n=220), 27% on bridging therapy with intravenous heparin or subcutaneous enoxaparin (n=123) and 66% were on antiplatelet therapy (aspirin or clopidegrol or both; n=303) at the time of device implantation. Twelve percent of the patients had chronic kidney disease (n=55). In multivariate regression analysis, after adjusting for anticoagulation and antiplatelet agents, chronic kidney disease was found to be a significant risk factor for pocket hematoma formation after ICD and pacemaker placement. An increase of 1.0 mg/dl in creatinine levels was associated with a nearly twofold increase in hematoma formation (OR, 1.99; 95% CI, 1.22-3.21; p=0.03). Conclusion: Chronic kidney disease is a significant risk factor for pocket hematoma formation after pacemaker and ICD placement, independent of anticoagulation and antiplatelet agents.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalJournal of Interventional Cardiac Electrophysiology
Volume29
Issue number3
DOIs
StatePublished - Dec 2010

Bibliographical note

Funding Information:
This work was supported in part by “Discovery Grants” from the HealthPartners Research Foundation, Minneapolis, Minnesota to Dr. Zhu and Dr. Ahmed. There is no financial relationship with HealthPartners Research Foundation. The authors have full control of all primary data and agree to allow the journal to review the data, if requested.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Anticoagulation
  • Defibrillator
  • Implantation
  • Pacemaker
  • Warfarin

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