Chronic multifocal osteomyelitis, a new recessive mutation on Chromosome 18 of the mouse

Linda Byrd; Michael Grossmann; Michael Potter; Grace L.C. Shen-Ong

doi:10.1016/0888-7543(91)90002-V

Chronic multifocal osteomyelitis, a new recessive mutation on Chromosome 18 of the mouse

Linda Byrd, Michael Grossmann, Michael Potter, Grace L.C. Shen-Ong

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Abstract

Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2⁺N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-2⁺- cmo cmo indicated that the cmo gene resides on mouse Chromosome 18.

Original language	English (US)
Pages (from-to)	794-798
Number of pages	5
Journal	Genomics
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0888-7543(91)90002-V
State	Published - Dec 1991
Externally published	Yes

Bibliographical note

Funding Information:
*Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; and t Guggenheim Mayo Medical Center, Rochester, Minnesota 55901

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title = "Chronic multifocal osteomyelitis, a new recessive mutation on Chromosome 18 of the mouse",

abstract = "Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-2+- cmo cmo indicated that the cmo gene resides on mouse Chromosome 18.",

author = "Linda Byrd and Michael Grossmann and Michael Potter and Shen-Ong, {Grace L.C.}",

note = "Funding Information: *Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; and t Guggenheim Mayo Medical Center, Rochester, Minnesota 55901",

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AU - Byrd, Linda

AU - Grossmann, Michael

AU - Potter, Michael

AU - Shen-Ong, Grace L.C.

N1 - Funding Information: *Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; and t Guggenheim Mayo Medical Center, Rochester, Minnesota 55901

PY - 1991/12

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AB - Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-2+- cmo cmo indicated that the cmo gene resides on mouse Chromosome 18.

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Chronic multifocal osteomyelitis, a new recessive mutation on Chromosome 18 of the mouse

Abstract

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