TY - JOUR
T1 - Chronic psychosocial stress-induced down-regulation of immunity depends upon individual factors
AU - Bartolomucci, Alessandro
AU - Sacerdote, Paola
AU - Panerai, Alberto E.
AU - Peterzani, Tiziana
AU - Palanza, Paola
AU - Parmigiani, Stefano
N1 - Funding Information:
This work was financially supported by the Italian MIUR and the University of Parma. The authors wish to thank V. Vascelli for technical assistance provided.
PY - 2003/8
Y1 - 2003/8
N2 - The effect of chronic stress on immune functions is strongly biased by individual factors. Mice were subjected to a new model of chronic psychosocial stress in which four different subcategories of stressed animals may be identified: Resident Dominants (RD), Resident Subordinates (RS), Intruder Dominants (InD), and Intruder Subordinates (InS). After 7 days of stress, mice were immunized with keyhole limpet hemocyanine (KLH). Their immune functions were investigated 14 days later with stress continuing trough. Importantly, RS mice, which are mice losing territory ownership, were the more affected, having lower IgG, proliferation, and IL-2. RD and InD showed lower IgG while InS showed no immune alteration. In conclusion, loss of resources could be a key factor in determining individual vulnerability to stressful events.
AB - The effect of chronic stress on immune functions is strongly biased by individual factors. Mice were subjected to a new model of chronic psychosocial stress in which four different subcategories of stressed animals may be identified: Resident Dominants (RD), Resident Subordinates (RS), Intruder Dominants (InD), and Intruder Subordinates (InS). After 7 days of stress, mice were immunized with keyhole limpet hemocyanine (KLH). Their immune functions were investigated 14 days later with stress continuing trough. Importantly, RS mice, which are mice losing territory ownership, were the more affected, having lower IgG, proliferation, and IL-2. RD and InD showed lower IgG while InS showed no immune alteration. In conclusion, loss of resources could be a key factor in determining individual vulnerability to stressful events.
KW - Body weight
KW - IL-2
KW - IgG
KW - Loss of resource
KW - Proliferation
KW - Subordination
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U2 - 10.1016/S0165-5728(03)00220-0
DO - 10.1016/S0165-5728(03)00220-0
M3 - Article
C2 - 12965254
AN - SCOPUS:0142107312
SN - 0165-5728
VL - 141
SP - 58
EP - 64
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -