Chronomics: Circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond

Franz Halberg, Germaine Cornélissen, Zhengrong Wang, Chaomin Wan, Waldemar Ulmer, George Katinas, Ranjana Singh, R. K. Singh, Rajesh Kumar Singh, B. D. Gupta, R. B. Singh, Adarsh Kumar, Eugene Kanabrocki, Robert B. Sothern, Gundu Rao, Madan L B Bhatt, Madhu Srivastava, Gulshan Rai, Subhash Singh, Atanu Kumar PatiPanchanan Nath, Francine Halberg, Julia Halberg, Othild Schwartzkopff, Earl Bakken, Shri Vishnu Kant Shastri

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.

Original languageEnglish (US)
Pages (from-to)223-260
Number of pages38
JournalJournal of Experimental Therapeutics and Oncology
Volume3
Issue number5
DOIs
StatePublished - Sep 2003

Keywords

  • Chronome
  • Chronomics
  • Chronotherapy
  • Circadian
  • Circaseptan
  • Nutriceuticals

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