Circadian and circaseptan dependence of the beta-ATP peak of four different cancer cell cultures: Implications for chronoradiotherapy

W. Ulmer, G. Cornelissen, M. Revilla, J. Siegelová, J. Dušek, F. Halberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The aim of the study was to examine the time-dependence of the beta-ATP peak of different tumor cells in vitro as a gauge of overall metabolism. In view of the large circaseptan-over-circadian prominence of the time-dependence of the beta-ATP peak, it is suggested to modulate the administration of radiotherapy according to a weekly schedule, to optimize treatment efficacy.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Volume74
Issue number2
StatePublished - 2001

Keywords

  • Beta-ATP peak
  • Cancer cell cultures
  • Circadian and circaseptan rhythm
  • Implications for chronoradiotherapy

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