Circadian periodicity of plasma lipid peroxides and other anti-oxidants as putative markers in gynecological malignancies

Ranjana Singh, Rajesh K. Singh, A. A. Mahdi, R. K. Singh, A. Kumar, A. K. Tripathi, R. Rai, Urmila Singh, G. Cornélissen, O. Schwartzkopff, Franz Halberg

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background: The chronome (from chronos, time, and nomos, rule), or time structure, of lipid peroxidation and anti-oxidant defense mechanisms may relate to prevention and curative chronochemotherapeutic efficacy and management. Patients and methods: Newly diagnosed women with gynecological malignancies (N=30), 30-60 years of age, and age-matched clinically healthy women (N=35) provided blood samples every 6 hours for 24 hours under standardized conditions. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities, and serum ascorbate, urate and high-density lipoprotein cholesterol (HDL-C) concentrations were determined. Results: Each variable underwent circadian variation (p≤0.002). Patients differed from controls by their overall chronome-adjusted mean value (MESOR) and by the circadian dynamics in the spectral element of their chronome. Conclusion: Chronomes of putative anti- and pro-oxidants should be mapped to explore their putative chemotherapeutic role as markers in cancer chronoprevention and management of established disease.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalIn Vivo
Volume17
Issue number6
StatePublished - 2003

Keywords

  • Anti-oxidant defense mechanisms
  • Chronome
  • Chronotherapy
  • Circadian
  • Gynecological cancer
  • Lipid peroxidation
  • Marker

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