Circadian phase difference of leptin in android versus gynoid obesity

Federico Perfetto, Roberto Tarquini, Germaine G Cornelissen-Guillaume, Giorgio Mello, Alessio Tempestini, Paola Gaudiano, Francesco Mancuso, Franz Halberg

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.

Original languageEnglish (US)
Pages (from-to)1297-1306
Number of pages10
JournalPeptides
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2004

Keywords

  • Body fat distribution (android versus gynoid)
  • Circadian rhythm
  • Cortisol
  • Insulin
  • Leptin

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