Circadian rhythms of adenosine deaminase activity in human erythrocytes: A transverse study on young, elderly and senile demented subjects

Germaine G Cornelissen-Guillaume, Yvan Touitou, George Tritsch, André Bogdan, André Auzéby, Alain Reinberg, Franz Halberg

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Adenosine deaminase activity (ADA) was determined around the clock in human plasma from different groups of subjects: presumably clinically healthy women in Minneapolis, USA; healthy medical students, healthy elderly men and women, and mentally will patients in Paris, France. In addition to analyses of variance, circadian characteristics were estimated individually and summarized by population-mean cosinor for each group. Technical and sampling considerations are documented: the individualized assessment of a circadian rhythm in adenosine deaminase is feasible in 8 out of 11 series from clinically healthy women covering 24h at 20-min intervals. A circadian population rhythm could be determined for the elderly men and women (p<0.05) and tentatively (p=0.053) for the senile demented patients. A difference in circadian group rhythm characteristics found between the healthy elderly subjects and patients with senile dementia deserves furhter exploration.

Original languageEnglish (US)
Pages (from-to)365-374
Number of pages10
JournalLa Ricerca in Clinica e in Laboratorio
Volume15
Issue number4
DOIs
StatePublished - Oct 1 1985

Keywords

  • Adenosine deaminase
  • Aging
  • Ciradian rhythms
  • Erythrocytes
  • Rhythmometry
  • Senile dementia
  • Women

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