TY - JOUR
T1 - Circular RNAs in Cardiovascular Disease
T2 - An Overview
AU - Fan, Ximin
AU - Weng, Xinyu
AU - Zhao, Yifan
AU - Chen, Wei
AU - Gan, Tianyi
AU - Xu, Dachun
N1 - Publisher Copyright:
© 2017 Ximin Fan et al.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.
AB - Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.
UR - http://www.scopus.com/inward/record.url?scp=85012231817&partnerID=8YFLogxK
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U2 - 10.1155/2017/5135781
DO - 10.1155/2017/5135781
M3 - Review article
C2 - 28210621
AN - SCOPUS:85012231817
SN - 2314-6133
VL - 2017
JO - BioMed Research International
JF - BioMed Research International
M1 - 5135781
ER -