TY - JOUR
T1 - Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients
AU - Baker, Jason V.
AU - Hullsiek, Katherine Huppler
AU - Bradford, Robert L.
AU - Prosser, Rachel
AU - Tracy, Russell P.
AU - Key, Nigel S.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Activation of coagulation pathways may contribute to risk for non-AIDS-related conditions among HIV-positive patients. Tissue factor (TF)-dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (-36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDSdefining complications.
AB - Activation of coagulation pathways may contribute to risk for non-AIDS-related conditions among HIV-positive patients. Tissue factor (TF)-dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (-36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDSdefining complications.
KW - Cardiovascular disease
KW - Coagulation
KW - HIV infection
KW - Inflammation
KW - Tissue factor activity
UR - http://www.scopus.com/inward/record.url?scp=84880202900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880202900&partnerID=8YFLogxK
U2 - 10.1097/QAI.0b013e3182910121
DO - 10.1097/QAI.0b013e3182910121
M3 - Article
C2 - 23507662
AN - SCOPUS:84880202900
SN - 1525-4135
VL - 63
SP - 367
EP - 371
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 3
ER -