TY - JOUR
T1 - Circulating vitamin D, supplement use, and cardiovascular disease risk
T2 - The MrOS sleep study
AU - Bajaj, Archna
AU - Stone, Katie L.
AU - Peters, Katherine
AU - Parimi, Neeta
AU - Barrett-Connor, Elizabeth
AU - Bauer, Doug
AU - Cawthon, Peggy M.
AU - Ensrud, Kristine E.
AU - Hoffman, Andrew R.
AU - Orwoll, Eric
AU - Schernhammer, Eva S.
N1 - Publisher Copyright:
© 2014 by the Endocrine Society.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Objective: To determine the association between serum 25(OH) vitamin D and risk for CVD events.Context: Evidence suggests an inverse association between circulating 25(OH) vitamin D and cardiovascular disease (CVD).Setting and Design: From March 2000 to April 2002, participants were recruited for the Osteoporotic Fractures in Men (MrOS) study. Between December 2003 and March 2005, members of the MrOS cohort were invited to participate in the MrOS Sleep Study. Participants were recruited from 6 clinical centers across the United States and followed for a mean of 5.9 years. Three-thousandone- hundred-thirty-fivemenages 65 and older were included from the MrOS cohort, ofwhom116 were excluded for missing vitaminDor CVD data. Participants were divided into two groups based on serum 25(OH) vitamin D levels,<20 ng/mL and≥20 ng/mL. Participants were followed for CVD endpoints including coronary heart disease (CHD) and cerebrovascular events. Age- and multivariable- adjusted hazard ratios were calculated and stratified by use of vitamin D containing supplements.Results: We observed no significant association between circulating 25(OH) vitamin D and risk of CVD event (HR, 0.91; 95% confidence interval (CI), 0.73-1.13) and CHD event (HR, 0.81; 95% CI, 0.61-1.07). For cerebrovascular events, men with vitamin D deficiency exhibited a higher risk (HR, 1.44; 95% CI, 1.00-2.08) using the minimally adjusted model and after excluding supplement users (HR, 1.70; 95% CI, 1.02-2.83).Conclusions: 25(OH) vitamin D was not associated with risk of CVD and CHD events. However, vitamin D deficiency may be associated with an increased risk of cerebrovascular events.
AB - Objective: To determine the association between serum 25(OH) vitamin D and risk for CVD events.Context: Evidence suggests an inverse association between circulating 25(OH) vitamin D and cardiovascular disease (CVD).Setting and Design: From March 2000 to April 2002, participants were recruited for the Osteoporotic Fractures in Men (MrOS) study. Between December 2003 and March 2005, members of the MrOS cohort were invited to participate in the MrOS Sleep Study. Participants were recruited from 6 clinical centers across the United States and followed for a mean of 5.9 years. Three-thousandone- hundred-thirty-fivemenages 65 and older were included from the MrOS cohort, ofwhom116 were excluded for missing vitaminDor CVD data. Participants were divided into two groups based on serum 25(OH) vitamin D levels,<20 ng/mL and≥20 ng/mL. Participants were followed for CVD endpoints including coronary heart disease (CHD) and cerebrovascular events. Age- and multivariable- adjusted hazard ratios were calculated and stratified by use of vitamin D containing supplements.Results: We observed no significant association between circulating 25(OH) vitamin D and risk of CVD event (HR, 0.91; 95% confidence interval (CI), 0.73-1.13) and CHD event (HR, 0.81; 95% CI, 0.61-1.07). For cerebrovascular events, men with vitamin D deficiency exhibited a higher risk (HR, 1.44; 95% CI, 1.00-2.08) using the minimally adjusted model and after excluding supplement users (HR, 1.70; 95% CI, 1.02-2.83).Conclusions: 25(OH) vitamin D was not associated with risk of CVD and CHD events. However, vitamin D deficiency may be associated with an increased risk of cerebrovascular events.
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U2 - 10.1210/jc.2013-4178
DO - 10.1210/jc.2013-4178
M3 - Article
C2 - 24670083
AN - SCOPUS:84907190423
SN - 0021-972X
VL - 99
SP - 3256
EP - 3262
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -