Abstract
A new analog of prostacyclin, 6,9-Thiaprostacyclin was infused intravenously in pentobarbital anesthetized cats in order to determine its hemodynamic and anti-platelet aggregating properties. At an infusion rate of 0.01 μmoles/kg/min, PGI2-S moderately decreased arterial blood pressure without altering heart rate of superior mesenteric artery flow or platelet aggregation responses to ADP. However, at 0.05 μmoles/kg/min, PGI2-S significantly reduced arterial blood pressure and significantly increased heart rate, and superior mesenteric artery flow. Moreover, at 0.05 μmoles/kg/min, PGI2-S inhibited ADP platelet aggregation by 80%. PGI2-S may be a useful agent in circulatory shock.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 259-263 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 16 1979 |
Bibliographical note
Funding Information:Adult male cats (2.5 to 3.5 kg) were anesthetized with pentobarbital sodium (30 mg/kg) given intravenously. Supplemental anesthetic was given as Supported in part by NHLBI Institute Contract No . HO-E 2931 from the NIH and by the Ischemia-Shock Research Institute of Thomas Jefferson University .