Abstract
The first iron complex capable of olefin cis-dihydroxylation in combination with H2O2 provides a functional model for Rieske dioxygenases. Mechanistic studies on the model reaction suggest the participation of an Fe(III)(η2-OOH) intermediate, with the oxygen atoms coming exclusively from H2O2 (see reaction scheme; L denotes a tris(6-methyl-2-pyridylmethyl)amine ligand, Solv = solvent). The similarities between the model and the enzymes strengthen the proposal that an Fe(III)- peroxo intermediate is involved in the enzymatic reactions.
Original language | English (US) |
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Pages (from-to) | 2227-2229 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 38 |
Issue number | 15 |
DOIs | |
State | Published - Aug 2 1999 |
Keywords
- Dihydroxylations
- Dioxygenases
- Enzyme mimetics
- Iron
- Oxidations