TY - JOUR
T1 - Class I alloantigen is sufficient for cytolytic T lymphocyte binding and transmembrane signaling
AU - Kane, Kevin P.
AU - Goldstein, Steven A.N.
AU - Mescher, Matthew F.
PY - 1988/12
Y1 - 1988/12
N2 - Based largely on antibody blocking studies, a number of surface “accessory” molecules on effector cytolytic T lymphocytes (CTL) have been implicated as having a role in mediating CTL binding and lysis of target cells, possibly via binding to ligands on the target cell surface. Despite this, cloned allogeneic CTL were able to specifically bind cell‐size, artificial membranes (pseudocytes) bearing only class I alloantigen. This binding triggered CTL degranulation, as measured by serine esterase release. Thus, class I alloantigen alone is both a necessary and sufficient ligand for specific binding and effective transmembrane signaling to occur.
AB - Based largely on antibody blocking studies, a number of surface “accessory” molecules on effector cytolytic T lymphocytes (CTL) have been implicated as having a role in mediating CTL binding and lysis of target cells, possibly via binding to ligands on the target cell surface. Despite this, cloned allogeneic CTL were able to specifically bind cell‐size, artificial membranes (pseudocytes) bearing only class I alloantigen. This binding triggered CTL degranulation, as measured by serine esterase release. Thus, class I alloantigen alone is both a necessary and sufficient ligand for specific binding and effective transmembrane signaling to occur.
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U2 - 10.1002/eji.1830181209
DO - 10.1002/eji.1830181209
M3 - Article
C2 - 3265386
AN - SCOPUS:0024268299
SN - 0014-2980
VL - 18
SP - 1925
EP - 1929
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 12
ER -