Background: This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. Methods: We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison. Results: Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices. Conclusions: Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction. (C) 2000 Society of Biological Psychiatry.
Bibliographical noteFunding Information:
This work was supported in part by grants from the National Institute of Mental Health (No. MN44643), the Medical Research Council of Canada, the National Health and Welfare Research Directorate of Canada, and the Psychology and Psychiatry Services at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Dr. Sponheim was supported by a training grant from the National Institute of Mental Health (No. MH17069) and the Eva O. Miller Fellowship from the University of Minnesota Graduate School.
- Brain morphology
- Ocular motor function