Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia

Scott R. Sponheim; Brett A. Clementz; William G. Iacono; Morton Beiser

doi:10.1016/S0006-3223(00)00907-0

Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia

Scott R. Sponheim, Brett A. Clementz, William G. Iacono, Morton Beiser

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Abstract

Background: This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. Methods: We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison. Results: Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices. Conclusions: Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction. (C) 2000 Society of Biological Psychiatry.

Original language	English (US)
Pages (from-to)	1088-1097
Number of pages	10
Journal	Biological psychiatry
Volume	48
Issue number	11
DOIs	https://doi.org/10.1016/S0006-3223(00)00907-0
State	Published - Dec 1 2000

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Institute of Mental Health (No. MN44643), the Medical Research Council of Canada, the National Health and Welfare Research Directorate of Canada, and the Psychology and Psychiatry Services at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Dr. Sponheim was supported by a training grant from the National Institute of Mental Health (No. MH17069) and the Eva O. Miller Fellowship from the University of Minnesota Graduate School.

Keywords

Brain morphology
Electroencephalogram
Ocular motor function
Psychosis
Schizophrenia
Symptomatology

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title = "Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia",

abstract = "Background: This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. Methods: We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison. Results: Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices. Conclusions: Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction. (C) 2000 Society of Biological Psychiatry.",

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author = "Sponheim, {Scott R.} and Clementz, {Brett A.} and Iacono, {William G.} and Morton Beiser",

note = "Funding Information: This work was supported in part by grants from the National Institute of Mental Health (No. MN44643), the Medical Research Council of Canada, the National Health and Welfare Research Directorate of Canada, and the Psychology and Psychiatry Services at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Dr. Sponheim was supported by a training grant from the National Institute of Mental Health (No. MH17069) and the Eva O. Miller Fellowship from the University of Minnesota Graduate School.",

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N2 - Background: This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. Methods: We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison. Results: Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices. Conclusions: Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction. (C) 2000 Society of Biological Psychiatry.

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Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia

Abstract

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