Clinical practice recommendations for the treatment of Alport syndrome: A statement of the Alport Syndrome Research Collaborative

Clifford E. Kashtan, Jie Ding, Martin Gregory, Oliver Gross, Laurence Heidet, Bertrand Knebelmann, Michelle Rheault, Christoph Licht

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin-angiotensin-aldosterone system.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalPediatric Nephrology
Volume28
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Aldosterone inhibitor
  • Alport syndrome
  • Angiotensin receptor blocker
  • Angiotensin-converting enzyme inhibitor
  • Proteinuria

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