TY - JOUR
T1 - Clinical significance of pulmonary nodules in the pretransplant evaluation of liver transplant recipients with hepatocellular carcinoma
AU - Serrano, Oscar
AU - Olgun, Deniz C.
AU - Goduguchinta, Varshita
AU - Bangdiwala, Ananta S
AU - Odegard, Marjorie N.
AU - Kandaswamy, Raja
AU - Matas, Arthur J
AU - Lake, John R
AU - Pruett, Timothy L
AU - Chinnakotla, Srinath
N1 - Publisher Copyright:
© Başkent University 2018 Printed in Turkey. All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - Objectives: Pulmonary nodules are common in patients with hepatocellular carcinoma who are being evaluated for a possible liver transplant. Materials and Methods: In this retrospective study, we analyzed the records of liver transplant recipients at our institution with a primary diagnosis of hepatocellular carcinoma who received transplants between 2000 and 2015. All patients had magnetic resonance imaging-confirmed disease within Milan criteria and a concurrent staging chest computed tomography. Patient survival was estimated using Kaplan-Meier methods and compared between pulmonary nodule characteristic groups. A Cox proportional hazards model was constructed for adjusted analysis. Results: Of the 197 liver transplant recipients who met our study inclusion criteria (median follow-up, 40 mo), 115 (58.4%) had a total of 231 pulmonary nodules, with 57 (49.6%) having multiple nodules and 108 (93.9%) having nodules < 1 cm. The presence of pulmonary nodules did not negatively affect patient survival, per our univariate and multivariate analysis, nor did their presence affect their number, location, laterality, shape, edge, density, or the presence of calcifications (P >.05). However, pulmonary nodules > 1 cm were associated with decreased overall survival. Conclusions: In our pretransplant evaluation of patients with hepatocellular carcinoma, pulmonary nodules < 1 cm did not portend worse patient or graft survival posttransplant.
AB - Objectives: Pulmonary nodules are common in patients with hepatocellular carcinoma who are being evaluated for a possible liver transplant. Materials and Methods: In this retrospective study, we analyzed the records of liver transplant recipients at our institution with a primary diagnosis of hepatocellular carcinoma who received transplants between 2000 and 2015. All patients had magnetic resonance imaging-confirmed disease within Milan criteria and a concurrent staging chest computed tomography. Patient survival was estimated using Kaplan-Meier methods and compared between pulmonary nodule characteristic groups. A Cox proportional hazards model was constructed for adjusted analysis. Results: Of the 197 liver transplant recipients who met our study inclusion criteria (median follow-up, 40 mo), 115 (58.4%) had a total of 231 pulmonary nodules, with 57 (49.6%) having multiple nodules and 108 (93.9%) having nodules < 1 cm. The presence of pulmonary nodules did not negatively affect patient survival, per our univariate and multivariate analysis, nor did their presence affect their number, location, laterality, shape, edge, density, or the presence of calcifications (P >.05). However, pulmonary nodules > 1 cm were associated with decreased overall survival. Conclusions: In our pretransplant evaluation of patients with hepatocellular carcinoma, pulmonary nodules < 1 cm did not portend worse patient or graft survival posttransplant.
KW - Extrahepatic cancer
KW - Metastases
KW - Radiologic assessment
KW - Transplant evaluation
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U2 - 10.6002/ect.2017.0227
DO - 10.6002/ect.2017.0227
M3 - Article
C2 - 29633930
AN - SCOPUS:85047928349
SN - 1304-0855
VL - 16
SP - 314
EP - 320
JO - Experimental and Clinical Transplantation
JF - Experimental and Clinical Transplantation
IS - 3
ER -