CLINICAL USEFULNESS OF MONOCLONAL- ANTIBODY PHENOTYPING IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA

John Kersey, Candice Abramson, Guy Perry, Anne Goldman, Mark Nesbit, Kazimiera Gajl-Peczalska, Tucker Lebien

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Lymphoblasts from 59 children with non-T, non-B acute lymphoblastic leukaemia were studied with monoclonal antibodies to four cell-surface proteins. 87% of the children had lymphoblasts positive for HLA-DR, 82% for p30, 75% for p24, and 72% for CALLA. The commonest composite phenotype was HLA-DR+ p30+ CALLA+ p24+. Significant correlations were seen between expression of HLA-DR, p30, and CALLA, but not p24. p30- and CALLA- phenotypes were found in patients with high white-blood-cell counts (WBC) and splenomegaly. With standard chemotherapy, disease-free survival from time of remission was shorter in p30- and CALLA- patients than in others. Splenomegaly was associated with poor disease-free survival and provided prognostic information independent of phenotype. High WBC was less significant than phenotype in predicting outcome and was not independent of phenotype.

Original languageEnglish (US)
Pages (from-to)1419-1423
Number of pages5
JournalThe Lancet
Volume320
Issue number8313
DOIs
StatePublished - Dec 25 1982

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Cancer

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